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He learned pediatric cardiac catheterization under the guidance of Dr. Mario Carminati. In he became the Director of the catheterisation laboratory at the Necker Hospital in Paris, France. Early in his career he showed interest in the strategic organisation of cardiology in developing countries, specifically in East Africa, where his interest in cardiovascular research led to the design of a cost effective catheter for the treatment of mitral stenosis Multi-Track System.

In he began a research program with the aim of replacing the pulmonary valve Melody without open heart surgery.

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Alain Cribier. Francis Fontan in In association with Medtronic he developed a valve for patients with pulmonary regurgitation in the absence of a surgically placed conduit. Throughout his career Philipp Bonhoeffer has followed his interests outside medicine. Since childhood he is an active musician playing the violin and the viola.

He has keen interest in violinmaking.